Suicide risk during antidepressant treatment
Simon GE, Savarino J, Operskalski B, Wang PS
AMERICAN JOURNAL OF PSYCHIATRY 163 (1): 41-47 JAN 2006
Simon GE, Savarino J, Operskalski B, Wang PS
AMERICAN JOURNAL OF PSYCHIATRY 163 (1): 41-47 JAN 2006
In March 2004 the U. S. Food and Drug Administration (FDA) warned physicians and patients regarding increased risk of suicide with 10 newer antidepressant drugs. Available data leave considerable uncertainty regarding actual risk of suicide attempt and death by suicide during antidepressant treatment. The authors used population-based data to evaluate the risk of suicide death and serious suicide attempt in relation to initiation of antidepressant treatment....
Conclusions: The risk of suicide during acute-phase antidepressant treatment is approximately one in 3,000 treatment episodes, and risk of serious suicide attempt is approximately one in 1,000. Available data do not indicate a significant increase in risk of suicide or serious suicide attempt after starting treatment with newer antidepressant drugs.